Enhanced Calcium Buffering in F344 Rat Cholinergic Basal Forebrain Neurons
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چکیده
1 Associated with Age-related Cognitive Impairment 2 3 David Murchison, Angelika N. McDermott, Candi L. LaSarge, Kathryn A. Peebles, 4 Jennifer L. Bizon 2 and William H. Griffith. 5 1 Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center and 6 2 Psychology, Texas A&M University, College Station TX 77843. 7 8 Running head: Ca buffering in cholinergic neurons during aging. 9 10 11 12 13 14 Correspondence: 15 William. H. Griffith, Ph.D. 16 NEXT Dept. Texas A&M University System HSC 17 228 Reynolds Bldg. College Station TX 77843-1114 18 Email: [email protected] 19 Phone: 979-845-4991 20 Fax: 979-845-0790 21 22 23 24 25 Articles in PresS. J Neurophysiol (August 12, 2009). doi:10.1152/jn.00301.2009
منابع مشابه
Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.
Alterations in neuronal Ca(2+) homeostasis are important determinants of age-related cognitive impairment. We examined the Ca(2+) influx, buffering, and electrophysiology of basal forebrain neurons in adult, middle-aged, and aged male F344 behaviorally assessed rats. Middle-aged and aged rats were characterized as cognitively impaired or unimpaired by water maze performance relative to young co...
متن کاملCharacterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.
Basal forebrain (BF) cholinergic neurons participate in a number of cognitive processes that become impaired during aging. We previously found that age-related enhancement of Ca(2+) buffering in rat cholinergic BF neurons was associated with impaired performance in the water maze spatial learning task (Murchison D, McDermott AN, Lasarge CL, Peebles KA, Bizon JL, and Griffith WH. J Neurophysiol ...
متن کاملIncreased calcium buffering in basal forebrain neurons during aging.
Increased calcium buffering in basal forebrain neurons during aging. J. Neurophysiol. 80: 350-364, 1998. Alterations of neuronal calcium (Ca2+) homeostasis are thought to underlie many age-related changes in the nervous system. Basal forebrain neurons are susceptible to changes associated with aging and to related dysfunctions such as Alzheimer's disease. It recently was shown that neurons from...
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تاریخ انتشار 2009